Dast Richtlinie 009 Pdf Creator

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Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of 215 pregnant women who were enrolled in our prior study. With additional data from telephone interviews regarding prenatal folic acid supplementation, existing demographic, maternal and fetal data were statistically analyzed.

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The concentration of folic acid in maternal blood was significantly higher following folic acid supplementation (24.6 ng/mL vs.11.8 ng/mL). In contrast, homocysteine level in maternal blood decreased with folic acid supplementation (5.5 µmol/mL vs.

Fileice Survey Remover Free Download No Survey. 6.8 µmol/mL). The rates of both preeclampsia (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.09–0.76) and small for gestational age (SGA; 9.2% vs. 20.0%; OR, 0.42; 95% CI, 0.18–0.99) were lower in the folic acid supplementation group than those in the control group.

Other pregnancy outcomes had no association with folic acid supplementation. The findings indicate that folic acid supplementation may help to prevent preeclampsia and SGA. Further studies are warranted to elucidate the favorable effects of folic acid supplementation on pregnancy outcomes. Introduction Overwhelming evidence supports the use of folic acid supplementation during pregnancy to prevent neural tube defects. Prenatal intake of folic acid has also been associated with better long-term neurodevelopment in offspring.

However, whether the protective effects of folic acid extend to other pregnancy outcomes have not been clearly identified. In a population-based prospective cohort study, maternal hyperhomocysteinemia was linked to a higher risk of adiposity and type 2 diabetes in mothers and their offspring.

Our prior study showed that lower folate and higher homocysteine concentrations in maternal serum at the time of delivery are associated with unfavorable pregnancy outcomes such as pre-term birth and pre-eclampsia. In this study, we determined whether antenatal folic acid supplementation is associated with favorable maternal and fetal outcomes. Materials and Methods This was a retrospective secondary analysis to a study group described previously. We obtained the approval of the Institutional Review Board in Korea University Anam Hospital (IRB No: ED12248). This study was exempt from participants’ informed consent because the investigator conducting research of this secondary analysis did not obtain information about research subjects via an interaction with them, nor did the investigator obtain identifiable private information. Briefly, the study population included women with singleton pregnancies who delivered at the Korea University Anam Hospital between June 1, 2009, and June 13, 2010 and provided informed consent. Maternal blood samples were collected during antenatal visits or upon admission to the hospital.

Cord blood samples were obtained from the umbilical vein immediately after delivery. Plasma total homocysteine concentration was measured using an automated enzymatic assay and homocysteine methyltransferase and d-amino acid oxidase (Toshiba 200FR-NEO Auto Analyzer; Toshiba Medical Systems Co., Ltd. Make The Teacher Walk The Plank Game on this page. , Tokyo, Japan). Folate level was measured using an iodine-125-based radioimmunoassay (Cobra II 5010; Packard, Meriden, CT, USA).

Among a total of 227 pregnant women reviewed initially, 215 cases were included in the study. Continuous variables are expressed as mean ± standard deviation or median (interquartile range [IQR]) values, whereas categorical variables are presented using their absolute values and percentages. Student’s t-test or the Wilcoxon rank-sum test was used for continuous variables; and the chi-square test or Fisher’s exact test were used for categorical variables. We performed a multivariable logistic regression analysis to analyze the associations between folic acid supplementation with other confounding factors such as parity, familial monthly income, preeclampsia, somatic classification of newborns. All statistical analyses were performed using SAS ver.